Colon Specific Polyelectrolyte Complexation Based Formulations of Losartan Potassium for Effective Management of Hypertension

The colon targeted drug delivery system has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery system has recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug [1]. The new techniques of drug delivery which makes the system capable of controlling the rate of drug delivery, sustaining the duration of therapeutic action and most focused on targeting the drugs to the specific sites have aroused as revolution in pharmaceutical field, thereby giving rise to the novel drug delivery system [2]. The electrostatic interactions between two or more opposite charged polyelectrolyte in solution form complex are called as polyelectrolyte complexes [3,4]. It involves interaction between the polymer-polymer, polymer-drug, and polymer-drug-polymer [5].